The 14-year-old sister of Coleen Rooney has died after a lifelong battle with a rare genetic disorder, a family spokesman said on Saturday.

Rosie McLoughlin, who had Rett syndrome, died at her home in Liverpool in the early hours of this morning surrounded by her family, the spokesman said.

A statement issued on behalf of Coleen, her husband, Manchester United star Wayne, and the rest of Rosie's family, said they had been left "heartbroken" by the teenager's death.

"She was such a strong little girl and an inspiration to us all," the statement said. "We shall cherish forever the memories we have shared and the love she showed us each and every day of her life."