More than 200 homes were flooded in York as the river Ouse burst its banks after days of torrential rain.
Heavy downpours swelled rivers and road networks were swamped by high water levels after the worst storms in September for 30 years.
Alison Baptiste, flood risk manager at the Environment Agency, said: "Flooding has a devastating impact on people, families and communities, and our thoughts are with those who have been flooded this week.
"We would urge people, especially in the North of England, to continue to be prepared for flooding, sign up for free flood warnings, keep up to date with the latest situation, and stay away from dangerous floodwater."
On Thursday morning, crews in Skeldergate, York, used a boat to transport carers into a residential home to administer medication to elderly residents.
A fire service spokesman said crews were also deployed to a caravan park at Bishopthorpe, near York, where there were reports of people stranded.